Weiss R B, Tormey D C, Holland J F, Weinberg V E
Cancer Treat Rep. 1981 Jul-Aug;65(7-8):677-9.
In a cooperative group study of 433 breast cancer patients treated with 2 years of postmastectomy chemotherapy, 22 (5%) developed venous thromboses of various types. Two patients died. None of the patients had demonstrable tumor metastases at the time of the venous thrombosis, although seven had metastases a median of 11 months after the thromboses. Thirteen living patients have not had tumor recurrences. No patient developed thrombosis after the chemotherapy was completed. It is possible that one or more of the chemotherapeutic agents initiated the clotting problems. Thrombophlebitis is a possible problem occurring during adjuvant chemotherapy for breast cancer and requires prompt treatment.
在一项针对433例接受两年乳房切除术后化疗的乳腺癌患者的合作组研究中，22例（5%）发生了不同类型的静脉血栓形成。两名患者死亡。在发生静脉血栓形成时，没有患者有可证实的肿瘤转移，尽管有7例在血栓形成后中位11个月出现转移。13名存活患者未出现肿瘤复发。化疗完成后没有患者发生血栓形成。有可能一种或多种化疗药物引发了凝血问题。血栓性静脉炎是乳腺癌辅助化疗期间可能出现的问题，需要及时治疗。
