Brennan M F
Br J Surg. 1984 Dec;71(12):964-7. doi: 10.1002/bjs.1800711219.
The management of soft tissue sarcomas presents one of the more exciting areas of the application of multimodal therapy for malignancy. Rapid developments have taken place in the understanding of the histogenesis, histopathology, prognostic indicators and treatment approaches. With the combination of local irradiation and adjuvant chemotherapy, limb sparing operations can now be widely advocated with amputation being reserved for proximal difficult lesions. Retroperitoneal sarcomas, however, remain a major challenge with little progress in results of therapy, other than improved operative morbidity in the last 10-15 years. Current prospective, randomized studies of the management policies designed to maximize survival while minimizing morbidity should provide further insights in the near future. Our current and past experience with more than 150 new cases each year allows a brief summary of the understanding and management of these difficult problems.
软组织肉瘤的治疗是恶性肿瘤多模式治疗应用中较为令人关注的领域之一。在对组织发生、组织病理学、预后指标及治疗方法的认识方面已取得了迅速进展。通过局部放疗与辅助化疗相结合，现在广泛提倡保肢手术，截肢仅用于近端难以处理的病变。然而，腹膜后肉瘤仍然是一个重大挑战，除了在过去10至15年手术发病率有所改善外，治疗效果进展甚微。目前旨在在使发病率最小化的同时最大化生存率的管理策略的前瞻性随机研究，应能在不久的将来提供更多见解。我们每年处理150多例新病例的当前及过去经验，使我们能够对这些难题的认识和处理做一个简要总结。
