Türker K S, Miles T S
Brain Res Bull. 1984 Aug;13(2):229-33. doi: 10.1016/0361-9230(84)90121-7.
A basic tenet of the Marr-Albus theory of motor learning is that the learning process involves concurrent activation of the climbing fibre and mossy fibre inputs to the cerebellum. This theory was tested by administering harmaline, a drug which causes climbing fibres to fire at their maximal rate of 8-12 Hz, to rabbits during a classical conditioning protocol. Harmaline significantly reduced the proportion of conditioned nictitating membrane responses on each of 4 successive training days. When harmaline was given to already-conditioned rabbits, the proportion of conditioned responses fell sharply to the day 1 level: however, this was still a higher proportion of conditioned trials than that which was seen with naive animals trained for 4 days with harmaline. It is therefore concluded that harmaline disrupts the acquisition of classically-conditioned nictitating membrane responses but does not prevent the expression of an already learnt response. These findings are therefore consistent with the proposal in the Marr-Albus theory that the climbing fibres play an essential part in motor learning.
马尔-阿尔布斯运动学习理论的一个基本信条是，学习过程涉及到攀缘纤维和苔藓纤维向小脑输入的同时激活。通过在经典条件反射实验中给兔子注射哈尔满（一种能使攀缘纤维以8 - 12赫兹的最大频率放电的药物）来检验这一理论。在连续4天的训练中，哈尔满显著降低了条件性瞬膜反应的比例。当给已经形成条件反射的兔子注射哈尔满时，条件反应的比例急剧下降到第1天的水平：然而，这一比例仍高于用哈尔满训练4天的未受过训练的动物所观察到的条件性试验比例。因此得出结论，哈尔满会干扰经典条件性瞬膜反应的习得，但不会阻止已习得反应的表达。所以这些发现与马尔-阿尔布斯理论中关于攀缘纤维在运动学习中起重要作用的提议是一致的。
