大鼠对环丙烷缺乏耐受性以及对氟烷存在交叉耐受性。
Lack of tolerance to cyclopropane and cross-tolerance to halothane in rats.
作者信息
Munson E S
出版信息
Can Anaesth Soc J. 1984 Nov;31(6):642-5. doi: 10.1007/BF03008760.
PMID:6498580
Abstract
Cyclopropane requirement (MAC) in rats was determined before, during, and after repeated exposure to anaesthetic concentrations of cyclopropane and halothane for one hour every day for 20 and 30 days, respectively. MAC values during and after exposure ranged from 93 to 103 per cent (mean = 99 per cent) of control values, which indicates a lack of significant tolerance to cyclopropane or a cross-tolerance between cyclopropane and halothane.
摘要
分别在大鼠每天暴露于麻醉浓度的环丙烷和氟烷1小时，持续20天和30天之前、期间和之后，测定其环丙烷需求（最低肺泡有效浓度）。暴露期间和之后的最低肺泡有效浓度值为对照值的93%至103%（平均为99%），这表明对环丙烷缺乏显著耐受性，或环丙烷与氟烷之间不存在交叉耐受性。
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