Inaba T, Nakano M, Otton S V, Mahon W A, Kalow W
Can J Physiol Pharmacol. 1984 Jul;62(7):860-2. doi: 10.1139/y84-144.
The present study compares the debrisoquine monooxygenase and the sparteine monooxygenase activities of human liver microsomes. In the presence of 14 competitive inhibitors, apparent inhibition constants (Ki) as determined by these two activities ranged over four orders of magnitude with a correlation coefficient 0.99. These in vitro results represent the strongest evidence to date that the debrisoquine monooxygenase and the sparteine monooxygenase are identical and involve a single isozyme of cytochrome P-450.
本研究比较了人肝微粒体中异喹胍单加氧酶和司巴丁单加氧酶的活性。在14种竞争性抑制剂存在的情况下，由这两种活性所测定的表观抑制常数（Ki）范围跨越四个数量级，相关系数为0.99。这些体外实验结果是迄今为止最有力的证据，表明异喹胍单加氧酶和司巴丁单加氧酶是相同的，且涉及细胞色素P - 450的单一同工酶。
