美芬妥因p(4')-羟化作用的基因多态性：东方人与高加索人的差异。
Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.
作者信息
Jurima M, Inaba T, Kadar D, Kalow W
出版信息
Br J Clin Pharmacol. 1985 Apr;19(4):483-7. doi: 10.1111/j.1365-2125.1985.tb02673.x.
Abstract
The genetically controlled mephenytoin p(4')-hydroxylation capacity was determined in 118 Caucasians and 70 Orientals. After an oral dose of 50 or 100 mg of racemic mephenytoin, the amount of p(4')-hydroxymephenytoin in 24 h urine was measured by gas chromatography. Bimodal distribution was found with 9/70 (13%) Orientals and 5/118 (4%) Caucasians demonstrating deficient p(4')-hydroxylation. The statistically significant difference between Orientals and Caucasians (P less than 0.05) was accounted for by the high incidence of poor metabolizers among the Japanese subjects, 7/31 (23%). The frequency among Chinese subjects, 2/39 (5%), was similar to the frequency among Caucasians.
摘要
在118名白种人和70名东方人中测定了基因控制的美芬妥因4'-羟化能力。口服50或100毫克消旋美芬妥因后，通过气相色谱法测定24小时尿液中4'-羟基美芬妥因的含量。发现双峰分布，70名东方人中有9名（13%）、118名白种人中有5名（4%）表现出4'-羟化缺陷。东方人和白种人之间具有统计学意义的差异（P<0.05）是由日本受试者中代谢不良者的高发生率造成的，31名中有7名（23%）。中国受试者中的发生率为2/39（5%），与白种人中的发生率相似。
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