Risdall R J, Brunning R D, Hernandez J I, Gordon D H
Cancer. 1984 Dec 15;54(12):2968-72. doi: 10.1002/1097-0142(19841215)54:12<2968::aid-cncr2820541226>3.0.co;2-4.
Histiocytic medullary reticulosis (HMR) was originally defined as a neoplastic disorder. Some cases reported as HMR have been characterized by a systemic proliferation of mature histiocytes showing hemophagocytosis, bone marrow necrosis, pancytopenia, hepatitis, and coagulopathy. Clinically, these patients have fever and constitutional symptoms and often have hepatosplenomegaly and lymphadenopathy. Although there is a high mortality rate, this process appears to be reactive and has been associated with active viral infection. Similar cases have been briefly described that were associated with other agents or disease processes, but concomitant viral infections were not excluded. Three characteristic examples of this hemophagocytic syndrome that were associated with bacterial sepsis are described. Active infection by those viruses that have previously been associated with the syndrome was excluded. It appears that the hemophagocytic syndrome may be associated with various types of active disseminated infections.
组织细胞性髓性网状细胞增生症（HMR）最初被定义为一种肿瘤性疾病。一些报告为HMR的病例表现为成熟组织细胞的全身性增殖，伴有噬血细胞现象、骨髓坏死、全血细胞减少、肝炎和凝血病。临床上，这些患者有发热和全身症状，常伴有肝脾肿大和淋巴结病。尽管死亡率很高，但这个过程似乎是反应性的，并且与活动性病毒感染有关。曾简要描述过与其他病原体或疾病过程相关的类似病例，但并未排除同时存在病毒感染的情况。本文描述了三例与细菌性败血症相关的这种噬血细胞综合征的典型病例。排除了先前与该综合征相关的那些病毒的活动性感染。看来噬血细胞综合征可能与各种类型的活动性播散性感染有关。
