Finlay-Jones J, Tillett E J, Dent L A, Kriek G W, McDonald P J
Cancer Lett. 1984 Oct;24(3):311-6. doi: 10.1016/0304-3835(84)90028-4.
A model of intraabdominal sepsis in the tumour-bearing host was established in order to study the interactions between host, tumour and infecting organisms. BALB/c mice bearing a transplanted tumour were given an intraperitoneal inoculum containing Bacteroides fragilis, Escherichia coli and bran as an abscess-potentiating agent. Tumour-bearing mice formed abscesses which were not significantly smaller than in controls except late in tumour growth. The bacterial contents of the abscesses were not significantly different to controls. In contrast, mice given an abscess-inducing mixture at or near the time of tumour cell inoculation had tumours which were significantly larger than in controls. The mechanism of tumour enhancement is not known.
为了研究宿主、肿瘤和感染生物体之间的相互作用，建立了荷瘤宿主腹腔内脓毒症模型。给携带移植瘤的BALB/c小鼠腹腔接种含有脆弱拟杆菌、大肠杆菌和作为脓肿增强剂的麸皮的接种物。荷瘤小鼠形成的脓肿除了在肿瘤生长后期外，并不比对照组明显小。脓肿中的细菌含量与对照组无显著差异。相比之下，在接种肿瘤细胞时或接近接种时给予脓肿诱导混合物的小鼠，其肿瘤明显大于对照组。肿瘤增强的机制尚不清楚。
