介导自然杀伤细胞样细胞毒性的细胞存在于人类迟发型超敏反应中。
Cells that mediate NK like cytotoxicity are present in the human delayed type hypersensitivity response.
作者信息
Tartof D, Yung C W, Curran J J, Livingston C, Thalji Z
出版信息
Clin Exp Immunol. 1984 Nov;58(2):462-9.
Abstract
By inducing delayed type hypersensitivity (DTH) responses under previously formed skin blisters we determined that cells which mediate natural killer (NK) like cytotoxicity are present in the DTH response in man. Similar levels of killing were not present in cells obtained from skin blisters not associated with positive DTH responses. The DTH response associated killer cell was found to be a mononuclear cell that had presumably undergone stimulation since it not only killed NK sensitive K-562 cells, but also NK resistant Daudi target cells.
摘要
通过在先前形成的皮肤水疱下诱导迟发型超敏反应（DTH），我们确定介导自然杀伤（NK）样细胞毒性的细胞存在于人类的DTH反应中。从与阳性DTH反应无关的皮肤水疱中获得的细胞不存在类似水平的杀伤作用。发现与DTH反应相关的杀伤细胞是一种单核细胞，推测它已经受到刺激，因为它不仅能杀死对NK敏感的K-562细胞，还能杀死对NK有抗性的Daudi靶细胞。
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