Modena M G, Benassi A, Mattioli G
Clin Cardiol. 1984 Nov;7(11):593-8. doi: 10.1002/clc.4960071107.
Amrinone, a new inotropic drug, was infused at a dosage of 2.5 mg/kg body weight in 14 patients affected by dilatative cardiomyopathy in New York Heart Association (NYHA) functional class III and IV. Cardiac index, mean arterial pressure, and some echocardiographic parameters were evaluated. Cardiac index (CI) increased from 2.03 +/- 0.24 to 2.82 +/- 0.43 1/min/m2 (p less than 0.001). Fractional shortening (FS) increased from 16.4 +/- 5.2 to 21.5 +/- 5.3% (p less than 0.05). End-diastolic and end-systolic diameters showed a significant reduction. Mean arterial pressure decreased from 90.7 +/- 88 to 87.3 +/- 8.4 mmHg (p less than 0.001), the end-systolic stress (ESS) decreased from 5.8 +/- 1 to 5.2 +/- 1 g/cm (p less than 0.001). Analyzing the relationship between FS and ESS, it was possible in some cases to suppose the presence of an important vasodilator effect of the drug. The afterload in 7 patients was therefore modified before and after infusion of the drug to analyze FS at the same levels of afterload. This was done to evaluate the vasodilator effect of amrinone. Examining the regression line of FS/ESS ratio it was possible to observe a predominant vasodilator effect in some patients, but in most, a sinergic action was noted. This may be useful for chronic treatment of congestive heart failure, reducing amrinone doses, and using it in association with other vasodilator drugs.
氨力农是一种新型的正性肌力药物，以2.5毫克/千克体重的剂量静脉输注给14例纽约心脏病协会（NYHA）心功能Ⅲ级和Ⅳ级的扩张型心肌病患者。评估了心脏指数、平均动脉压和一些超声心动图参数。心脏指数（CI）从2.03±0.24升/分钟/平方米增加到2.82±0.43升/分钟/平方米（p＜0.001）。缩短分数（FS）从16.4±5.2增加到21.5±5.3%（p＜0.05）。舒张末期和收缩末期直径显著减小。平均动脉压从90.7±8.8降至87.3±8.4毫米汞柱（p＜0.001），收缩末期应力（ESS）从5.8±1降至5.2±1克/平方厘米（p＜0.001）。分析FS与ESS之间的关系，在某些情况下可以推测该药物存在重要的血管扩张作用。因此，在7例患者中，在输注药物前后改变后负荷，以分析相同后负荷水平下的FS。这样做是为了评估氨力农的血管扩张作用。检查FS/ESS比值的回归线，可以观察到一些患者有主要的血管扩张作用，但在大多数患者中，观察到的是协同作用。这对于充血性心力衰竭的慢性治疗、减少氨力农剂量以及与其他血管扩张药物联合使用可能是有用的。
