Sandberg M, Thune P
Contact Dermatitis. 1984 Sep;11(3):168-73. doi: 10.1111/j.1600-0536.1984.tb00965.x.
The allergenic potential of the aromatic lichen substance atranorin has been investigated by means of the guinea pig maximization test of Magnusson & Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among our patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. 4 patients with proven contact sensitivity to atranorin, evernic, usnic or physodic acid, were examined with different dilutions from 0.001 to 0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction.
已通过Magnusson和Kligman的豚鼠最大化试验研究了芳香地衣物质阿特拉诺林的致敏潜力。30%的动物诱发了敏感性，这相当于中等致敏能力（III级）。这与我们患者中临床观察到的1.5%的频率一致。对相同动物进行了改良的光过敏试验，但照射并未增加阳性反应的数量。对4名已证实对阿特拉诺林、扁枝衣酸、松萝酸或石耳酸有接触敏感性的患者，用0.001%至0.1%的不同稀释度进行了检查。试验系列的照射未引发任何明确的光过敏反应。
