Zaneveld L J, Goldsmith A
Contraception. 1984 Aug;30(2):161-7. doi: 10.1016/0010-7824(84)90100-8.
The effects of slow- and fast-releasing quinacrine pellets and tetracycline tablets on the genital tracts of 20 cynomolgus monkeys was evaluated. After surgical implantation of the pellets, the primates were observed for three months. No signs of toxic effects to the drugs were observed during the three-month period and on autopsy. Histopathological evaluation of the fallopian tubes, cervix, ovaries and uterus (except the endometrium) indicated they were all within normal limits. In no case were the uterotubal junctions obstructed. Endometrial changes were more frequent for quinacrine-treated monkeys. The results of the study point to the need for additional research regarding the optimal dose and duration of quinacrine administration.
评估了缓释和速释奎纳克林微丸及四环素片对20只食蟹猴生殖道的影响。在手术植入微丸后，对这些灵长类动物进行了三个月的观察。在这三个月期间以及尸检时均未观察到药物的毒性作用迹象。对输卵管、子宫颈、卵巢和子宫（子宫内膜除外）的组织病理学评估表明，它们均在正常范围内。无一例子宫输卵管连接处受阻。接受奎纳克林治疗的猴子子宫内膜变化更为频繁。该研究结果表明需要对奎纳克林给药的最佳剂量和持续时间进行更多研究。
