Brooks J E
J Hyg (Lond). 1978 Jun;80(3):401-8. doi: 10.1017/s0022172400024852.
The properties of pyriminyl (N-3-pyridylmethyl-N'-p-nitrophenyl urea) as a rodenticide against the lesser bandicoot rat (Bandicota bengalensis) in Rangoon, Burma, were investigated in the laboratory. The acute LD 50 and LD 95 dose of orally administered pyriminyl for B. bengalensis were found to be 6.7 mg/kg and 23.0 mg/kg of body weight respectively. When caged bandicoots were given a choice between plain and poisoned baits, the optimum rodenticidal concentration in the bait was found to be 0.25-0.5%. Symptoms of pyriminyl poisoning appear from 1 to 4 h after feeding starts, giving individual animals time to consume from 2 to over 30 LD 50 doses of 0.5% pyriminyl before feeding stops. Deaths occurred from 4 to 96 h after either oral dosing or free-choice feeding. There appeared to be no significant aversion to the poison at 0.25% or 0.5% concentration in foods. The potential hazards and use of pyriminyl as a field bait against populations of B. bengalensis are discussed.
在实验室中研究了嘧啶基（N - 3 - 吡啶基甲基 - N' - 对硝基苯基脲）作为杀鼠剂对缅甸仰光地区小板齿鼠（板齿鼠属）的特性。经口给予小板齿鼠嘧啶基的急性半数致死剂量（LD50）和95%致死剂量（LD95）分别为6.7毫克/千克体重和23.0毫克/千克体重。当将关在笼中的板齿鼠置于普通饵料和有毒饵料之间进行选择时，发现饵料中的最佳杀鼠浓度为0.25 - 0.5%。嘧啶基中毒症状在开始喂食后1至4小时出现，这使得个体动物在停止进食前有时间摄取2至超过30个0.5%嘧啶基的LD50剂量。口服给药或自由选择喂食后4至96小时出现死亡。在食物中0.25%或0.5%浓度的毒药似乎没有明显的拒食现象。讨论了嘧啶基作为针对小板齿鼠种群的田间饵料的潜在危害和用途。
