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急性哮喘患者吸入沙丁胺醇后动脉血氧饱和度下降

Arterial oxygen desaturation following salbutamol inhalation in acute asthma.

作者信息

Tal A, Pasterkamp H, Leahy F

出版信息

Chest. 1984 Dec;86(6):868-9. doi: 10.1378/chest.86.6.868.

DOI:10.1378/chest.86.6.868
PMID:6499548
Abstract

The practicality and accuracy of a new ear oximeter was evaluated. The SaO2 measured with this instrument correlated significantly with simultaneous SaO2 measurements with another ear oximeter in 12 children (age three months to 20 years) with chronic pulmonary or cardiac diseases (r = 0.93, p less than 0.001), and also correlated significantly (r = 0.96, p less than 0.001) with calculated SaO2 based on blood gas measurements of blood from the left side of the heart obtained during cardiac catheterization. The SaO2 was then measured continuously and readings were taken before and five, 15, and 30 minutes after salbutamol inhalation by face mask in 18 children. Following treatment, mean PEFR increased significantly, and mean SaO2 was significantly lower than preinhalation values at five and 15 minutes postinhalation. At 30 minutes, SaO2 had returned to control values. In nine of 18 subjects, SaO2 fell greater than or equal to 5 percent. This response was not predictable on the basis of different parameters (treatment, heart rate, PEFR). The findings suggest that supplemental O2 may be required during the first 30 minutes posttreatment.

摘要

对一种新型耳式血氧仪的实用性和准确性进行了评估。在12名患有慢性肺部或心脏疾病(年龄从3个月至20岁)的儿童中,用该仪器测得的血氧饱和度(SaO2)与同时用另一台耳式血氧仪测得的SaO2显著相关(r = 0.93,p < 0.001),并且与基于心导管插入术期间从心脏左侧采集的血液进行血气测量所计算出的SaO2也显著相关(r = 0.96,p < 0.001)。然后对18名儿童进行连续的SaO2测量,并在面罩吸入沙丁胺醇之前以及吸入后5分钟、15分钟和30分钟时读取数据。治疗后,平均呼气峰流速(PEFR)显著增加,并且吸入后5分钟和15分钟时的平均SaO2显著低于吸入前的值。在30分钟时,SaO2已恢复至对照值。在18名受试者中有9名,SaO2下降大于或等于5%。这种反应无法根据不同参数(治疗、心率、PEFR)进行预测。这些发现表明,治疗后最初30分钟内可能需要补充氧气。

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