Zatula D G, Bikhunov V L, Zagoruĭko E E
Eksp Onkol. 1984;6(1):47-9.
The frequency of tumour recurrences in A/Sn mice with operated Ehrlich carcinomas and treated with lyophylized antitumour vaccine and trypan blue or both of them was investigated. The tumours in vaccinated mice relapsed by the 47th day after the operation in 10% of cases, in 50% of control animals, the injection of trypan blue increased the tumour recurrences by 20%. The antitumour effect of vaccination is associated with the enhancement of the activity of the cellular and humoral immune systems. The trypan blue inhibition of the macrophage function suppresses the antitumor activity of the immunity cellular components.
研究了对患有艾氏癌并接受手术治疗的A/Sn小鼠，使用冻干抗肿瘤疫苗和台盼蓝或两者同时使用后肿瘤复发的频率。接种疫苗小鼠的肿瘤在术后第47天复发的情况在10%的病例中出现，而在50%的对照动物中出现，注射台盼蓝使肿瘤复发率增加了20%。疫苗接种的抗肿瘤作用与细胞和体液免疫系统活性的增强有关。台盼蓝对巨噬细胞功能的抑制作用会抑制免疫细胞成分的抗肿瘤活性。
