[Proliferative activity and cytotoxic effect of mouse lymphocytes during the growth of transplanted melanoma B-16].

The PHA stimulated proliferative activity of C57B1 mice lymphocytes and cell-mediated cytotoxicity on tumour target cells in vitro were studied during the transplantable melanoma B16 growth. The lymphocyte stimulation was shown to take place in all studied periods of the tumour growth with the exception of the terminal stage. The kinetics of cytotoxic activity during the melanoma B16 growth is characterized by rises and falls in the lymphocyte cytotoxicity. The maximum of proliferative activity of lymphocytes coincides with the minimum of their cytotoxic effect on the tumour cells.