[移植性黑色素瘤B-16生长过程中小鼠淋巴细胞的增殖活性和细胞毒性作用]
[Proliferative activity and cytotoxic effect of mouse lymphocytes during the growth of transplanted melanoma B-16].
作者信息
Korosteleva T A, Veresova O V
出版信息
Eksp Onkol. 1984;6(1):53-5.
The PHA stimulated proliferative activity of C57B1 mice lymphocytes and cell-mediated cytotoxicity on tumour target cells in vitro were studied during the transplantable melanoma B16 growth. The lymphocyte stimulation was shown to take place in all studied periods of the tumour growth with the exception of the terminal stage. The kinetics of cytotoxic activity during the melanoma B16 growth is characterized by rises and falls in the lymphocyte cytotoxicity. The maximum of proliferative activity of lymphocytes coincides with the minimum of their cytotoxic effect on the tumour cells.
在可移植性黑色素瘤B16生长过程中，研究了PHA刺激的C57B1小鼠淋巴细胞增殖活性以及体外对肿瘤靶细胞的细胞介导细胞毒性。结果表明，除终末期外，在肿瘤生长的所有研究阶段均发生淋巴细胞刺激。黑色素瘤B16生长过程中细胞毒性活性的动力学特征是淋巴细胞细胞毒性有升有降。淋巴细胞增殖活性的最大值与它们对肿瘤细胞的细胞毒性作用的最小值一致。
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