Korosteleva T A, Veresova O V
Vopr Onkol. 1980;26(1):67-70.
Lymphocytes and sera in mice with melanoma B16 and in intact mice render a cytotoxic effect on melanoma B16 cells in vitro. Lymphocytes in intact mice possess the maximum cytotoxicity for tumor cells, taken at the 20th day since the tumor inoculation, while the cytotoxic effect of mice melanoma B16 lymphocytes during this period proves to be markedly reduced. The kinetics of immune indices during the melanoma B16 growth in mice is characterized by rise and fall in the lymphocyte and sera cytotoxicity.
患有黑色素瘤B16的小鼠以及正常小鼠的淋巴细胞和血清在体外对黑色素瘤B16细胞具有细胞毒性作用。正常小鼠的淋巴细胞在肿瘤接种后第20天对肿瘤细胞具有最大细胞毒性，而在此期间患有黑色素瘤B16的小鼠淋巴细胞的细胞毒性作用则明显降低。小鼠黑色素瘤B16生长过程中免疫指标的动力学特征是淋巴细胞和血清细胞毒性的升降变化。
