[给大鼠肠胃外注射氨基比林和亚硝酸盐后形成N-二甲基亚硝胺的可能性]
[Possibility of N-dimethylnitrosamine formation after parenteral administration of amidopyrine and nitrite to rats].
作者信息
Rubenchik B L, Tsapenko V F, Boĭm T M
出版信息
Eksp Onkol. 1984;6(3):70-1.
PMID:6499745
Abstract
The intravenous or intraperitoneal injection of amidopyrine and sodium nitrite to rats induces liver necrosis caused by endogenic synthesis of carcinogenic N-nitrosodimethylamine (NDMA). Ascorbic acid, which inhibits this synthesis when injected intravenously, phenobarbital, which is an inductor of enzymatic decomposition when injected intraperitoneally, prevented the formation of necrosis.
摘要
给大鼠静脉注射或腹腔注射氨基比林和亚硝酸钠会诱导肝脏坏死，这种坏死是由致癌物质N-亚硝基二甲胺（NDMA）的内源性合成引起的。静脉注射时可抑制这种合成的抗坏血酸，腹腔注射时作为酶分解诱导剂的苯巴比妥，可防止坏死的形成。
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