Pavlásek J, Kundrát J
Exp Neurol. 1984 Dec;86(3):415-33. doi: 10.1016/0014-4886(84)90078-5.
A method of recording ensemble reactions of reticular neurons was applied in anesthetized cats to obtain information about categorization of inputs and the influence of the time factor upon a pattern of responses, reactions to stimulus intensity changes and to complex stimuli, and temporal influences with their relation to plastic changes induced by iterative stimulation. In spite of some variability of the pattern of responses evoked in the reticular formation (RF) by electrical stimulation of the same source, reactions of the parenchyma of the RF differentiate heterotopic stimuli; reactions evoked from receptor areas situated closely to each other exhibited a similar pattern whereas less resemblance was found in the case of responses evoked from sources with a heterosegmental projection and from contralateral sources. Stimulus intensity changes did not influence substantially the pattern of recordings in the RF. The noticeable effect resulting from the increase of stimulus intensity was enlargement of responses. A complex stimulus (two heterotopic stimuli applied simultaneously) was manifested by a reaction which, in comparison with reactions evoked from each of both sources separately, had a different pattern. A trend of changes in the size of responses evoked in the RF by continuous stimulation (60 stimuli, 0.3 Hz) was observed only in some cases. Abrupt alterations of the stimulation rate (0.3 Hz in equilibrium 1 Hz, 0.3 Hz in equilibrium 2 Hz) resulted in a prompt change in responses. With constant stimulation conditions, this activity was fairly constant with an absence of trends. Persistent changes were observed only in a minority of cases. The neuronal apparatus of the RF computes ongoing effects on the basis of ability to discriminate different inputs and to readily change its function. The extent to which the RF holds information about the antecedent "history" of its functioning and the extent to which intrinsic mechanisms of the RF by itself are responsible for behavioral habituation remains problematical.
在麻醉猫身上应用一种记录网状神经元群体反应的方法，以获取有关输入分类以及时间因素对反应模式、对刺激强度变化和复杂刺激的反应的影响，以及时间影响与重复刺激诱导的可塑性变化之间关系的信息。尽管相同来源的电刺激在网状结构（RF）中诱发的反应模式存在一定变异性，但RF实质的反应能够区分不同部位的刺激；彼此位置相近的感受器区域诱发的反应表现出相似的模式，而来自具有异节段投射的来源和对侧来源诱发的反应之间的相似性则较小。刺激强度的变化对RF中的记录模式没有实质性影响。刺激强度增加产生的显著效应是反应增大。复合刺激（同时施加两个不同部位的刺激）表现出一种反应，与分别从两个来源中的每一个诱发的反应相比，其模式不同。仅在某些情况下观察到RF中连续刺激（60次刺激，0.3赫兹）诱发的反应大小的变化趋势。刺激频率的突然改变（平衡时0.3赫兹变为1赫兹，平衡时0.3赫兹变为2赫兹）导致反应迅速变化。在恒定刺激条件下，这种活动相当稳定，没有变化趋势。仅在少数情况下观察到持续变化。RF的神经元机制基于区分不同输入和随时改变其功能的能力来计算持续效应。RF保留其功能先前“历史”信息的程度以及RF自身的内在机制对行为习惯化负责的程度仍然存在问题。
