Pax R A, Siefker C, Bennett J L
Exp Parasitol. 1984 Dec;58(3):314-24. doi: 10.1016/0014-4894(84)90048-1.
The physiological and pharmacological properties of circular and longitudinal somatic musculature in adult male Schistosoma mansoni were compared using cut muscle sections. Carbachol reduced tone in both circular and longitudinal muscle, but was without effect on circular muscle bathed in high Mg2+, indicating that cholinergic receptors were not associated with circular muscle membrane. 5-Hydroxytryptamine (5-HT) induced rhythmic contractile activity in both sets of muscle. It decreased muscle tone in circular muscle but increased the tone of longitudinal muscle. Metergoline blocked 5-HT effects on both sets of muscle. 5-HT continued to be effective on both sets of muscle bathed in high-Mg2+ medium, indicating that serotonergic receptors were present on both circular and longitudinal muscle membranes. Dopamine decreased both circular and longitudinal muscle tone. Its effects on circular muscle were still present after exposure to high Mg2+, but its effects on the longitudinal muscle were significantly reduced, leading to the conclusion that dopaminergic sites were probably associated with circular muscle membrane but not that of longitudinal muscle. Also, spiroperidol blocked stimulus responsiveness of the circular muscle but not that of the longitudinal muscle. From these studies it appears that there are significant physiological and pharmacological differences between circular and longitudinal muscles in the adult male schistosome.
使用切断的肌肉切片比较了成年雄性曼氏血吸虫环形和纵形体壁肌肉的生理和药理特性。卡巴胆碱可降低环形肌和纵形肌的张力，但对浸泡在高镁离子溶液中的环形肌无影响，这表明胆碱能受体与环形肌细胞膜无关。5-羟色胺（5-HT）可诱导两组肌肉产生节律性收缩活动。它可降低环形肌的张力，但增加纵形肌的张力。美替拉酮可阻断5-HT对两组肌肉的作用。5-HT对浸泡在高镁离子溶液中的两组肌肉仍有作用，这表明5-羟色胺能受体存在于环形肌和纵形肌细胞膜上。多巴胺可降低环形肌和纵形肌的张力。暴露于高镁离子溶液后，其对环形肌的作用仍然存在，但其对纵形肌的作用显著减弱，由此得出结论，多巴胺能位点可能与环形肌细胞膜有关，而与纵形肌细胞膜无关。此外，螺哌啶可阻断环形肌的刺激反应性，但不能阻断纵形肌的刺激反应性。从这些研究看来，成年雄性血吸虫的环形肌和纵形肌之间存在显著的生理和药理差异。
