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Does the complex of aminoacyl-tRNA synthetases and tRNA-modifying enzymes prevent miscoding?

作者信息

Ryazanov A G

出版信息

FEBS Lett. 1984 Dec 3;178(1):6-9. doi: 10.1016/0014-5793(84)81228-4.

DOI:10.1016/0014-5793(84)81228-4
PMID:6500064
Abstract

Several aminoacyl-tRNA synthetases of higher eukaryotes have always been found as multienzyme complexes. There are indications that these complexes can be associated with some tRNA-modifying enzymes. The function of such complexes is unclear. I have noticed that 6 out of 7 aminoacyl-tRNA synthetases most commonly occurring in complexes correspond to a group of tRNAs which must always contain a modified U in the first position of their anticodons. A hypothesis is proposed according to which association of 6 aminoacyl-tRNA synthetases with U-modifying enzymes can protect a cell from miscoding.

摘要

相似文献

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引用本文的文献

1
Multienzyme complex of aminoacyl-tRNA synthetases: an essence of being eukaryotic.氨酰-tRNA合成酶多酶复合体：真核生物的本质所在。
Biochem J. 1986 Oct 15;239(2):249-55. doi: 10.1042/bj2390249.
2
Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states.生理和病理状态下的高等真核生物氨酰-tRNA合成酶
Mol Cell Biochem. 1986 Aug;71(2):107-20. doi: 10.1007/BF00214769.