Dang C V, Dang C V
Mol Cell Biochem. 1986 Aug;71(2):107-20. doi: 10.1007/BF00214769.
The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5', 5''-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.
氨酰-tRNA合成酶在细胞代谢中发挥双重作用，即合成氨酰-tRNA和一种奇特的二核苷酸5', 5''-P1, P4-四磷酸腺苷，后者似乎参与DNA复制和细胞增殖的调控。本文综述了关于高等真核生物氨酰-tRNA合成酶的结构、遗传学、细胞生物学、生理学、在肿瘤形成中的作用以及在自身免疫性肌炎中的作用的最新研究成果。
