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黏膜抗菌免疫机制。

Mechanisms of antibacterial immunity of mucous membranes.

作者信息

Franĕk J, Libich J, Kubín V

出版信息

Folia Microbiol (Praha). 1984;29(5):375-84. doi: 10.1007/BF02887765.

DOI:10.1007/BF02887765
PMID:6500406
Abstract

A survey based on both literary data and the authors own results, concerning the mechanisms of sIgA-mediated antibacterial immunity, is presented. Secretory IgA is characterized as a specific component of the immune system of mucous membranes, which can recognize harmful bacterial and distinguish them from indigenous microflora physiologically colonizing the mucous membranes, to fix them to the mucous membrane surface and to direct further factors, such as mucin, lysozyme, etc. (which form the effector component of the mucous membrane immunity system) for their final inactivation and neutralization.

摘要

本文基于文献数据和作者自身研究成果,对分泌型免疫球蛋白A(sIgA)介导的抗菌免疫机制进行了综述。分泌型免疫球蛋白A是黏膜免疫系统的一种特异性成分,它能够识别有害细菌,并将其与正常定植于黏膜的本土微生物区分开来,进而将这些有害细菌固定在黏膜表面,并引导诸如黏蛋白、溶菌酶等其他因子(这些因子构成了黏膜免疫系统的效应成分)对其进行最终的灭活和中和。

相似文献

1
Mechanisms of antibacterial immunity of mucous membranes.黏膜抗菌免疫机制。
Folia Microbiol (Praha). 1984;29(5):375-84. doi: 10.1007/BF02887765.
2
Passive acquired mucosal immunity to group A streptococci by secretory immunoglobulin A.通过分泌型免疫球蛋白A获得对A组链球菌的被动获得性黏膜免疫。
J Exp Med. 1988 Jun 1;167(6):1945-50. doi: 10.1084/jem.167.6.1945.
3
[Mucosal immune systems--frontline of the biological defence mechanism].[黏膜免疫系统——生物防御机制的前沿]
Nihon Jibiinkoka Gakkai Kaiho. 2011 Nov;114(11):843-50. doi: 10.3950/jibiinkoka.114.843.
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Mucosal antibodies to Haemophilus influenzae type b capsular polysaccharide.针对b型流感嗜血杆菌荚膜多糖的黏膜抗体。
Pediatr Res. 1991 May;29(5):420-3. doi: 10.1203/00006450-199105010-00002.
5
Comparative in vivo analysis of IgA- and IgG-mediated mucosal defense against bacterial pathogens.针对细菌病原体的IgA和IgG介导的黏膜防御的体内比较分析。
Behring Inst Mitt. 1997 Feb(98):53-5.
6
Bacterial adherence to mucosal surfaces and its inhibition by secretory antibodies.细菌对黏膜表面的黏附及其被分泌性抗体的抑制作用。
Adv Exp Med Biol. 1974;45(0):315-25. doi: 10.1007/978-1-4613-4550-3_38.
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Mucosal immunity to Pseudomonas aeruginosa alginate in cystic fibrosis.囊性纤维化患者对铜绿假单胞菌藻酸盐的黏膜免疫
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Synthesis in vitro of immunoglobulins produced by different human mucous membranes.不同人体黏膜产生的免疫球蛋白的体外合成
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Adv Exp Med Biol. 1987;216B:1741-7.
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Secretory immunoglobulin A in oral and respiratory passages in man.人体口腔和呼吸道中的分泌型免疫球蛋白A
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The role of glycosylated mucins in maintaining intestinal homeostasis and gut health.糖基化粘蛋白在维持肠道内环境稳定和肠道健康中的作用。
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Antibacterial immunity of lower airways: local or localized?下呼吸道的抗菌免疫:局部的还是局限的?
Folia Microbiol (Praha). 1985;30(3):247-57. doi: 10.1007/BF02923517.
3
Intestinal mucus gel and secretory antibody are barriers to Campylobacter jejuni adherence to INT 407 cells.肠道黏液凝胶和分泌性抗体是空肠弯曲菌黏附INT 407细胞的屏障。

本文引用的文献

1
Mechanism of Action of Intestinal Antibody in Experimental Cholera II. Antibody-Mediated Antibacterial Reaction at the Mucosal Surface.肠抗体在实验性霍乱中的作用机制 II. 黏膜表面的抗体介导的抗菌反应。
Infect Immun. 1970 Nov;2(5):556-62. doi: 10.1128/iai.2.5.556-562.1970.
2
CHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS.某些外分泌液共有的免疫系统特征。
J Exp Med. 1965 Jan 1;121(1):101-24. doi: 10.1084/jem.121.1.101.
3
THE SELECTIVE OCCURENCE OF GAMMA-1A GLOBULINS IN CERTAIN BODY FLUIDS.γ-1A球蛋白在某些体液中的选择性出现。
Infect Immun. 1987 Jun;55(6):1431-5. doi: 10.1128/iai.55.6.1431-1435.1987.
J Clin Invest. 1963 Oct;42(10):1552-60. doi: 10.1172/JCI104840.
4
Cellular dissemination of priming for a mucosal immune response to cholera toxin in rats.大鼠中霍乱毒素黏膜免疫反应启动的细胞扩散
J Immunol. 1981 Dec;127(6):2461-4.
5
Bacterial aggregating activity in human saliva: comparisons of bacterial species and strains.人类唾液中的细菌聚集活性:细菌种类和菌株的比较
Infect Immun. 1981 Mar;31(3):1003-6. doi: 10.1128/iai.31.3.1003-1006.1981.
6
Immunoglobulin A antibody levels in human tears, saliva, and serum.人眼泪、唾液和血清中的免疫球蛋白A抗体水平。
Infect Immun. 1982 Jun;36(3):1019-22. doi: 10.1128/iai.36.3.1019-1022.1982.
7
Adherence of Shigella flexneri to guinea pig intestinal cells is mediated by a mucosal adhesion.弗氏志贺菌对豚鼠肠道细胞的黏附是由一种黏膜黏附素介导的。
Infect Immun. 1982 Mar;35(3):1110-8. doi: 10.1128/iai.35.3.1110-1118.1982.
8
Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface.细菌黏附:介导细菌附着于黏膜表面的黏附素-受体相互作用。
J Infect Dis. 1981 Mar;143(3):325-45. doi: 10.1093/infdis/143.3.325.
9
Evidence for a common mucosal immunologic system. II. Influence of the estrous cycle on B immunoblast migration into genital and intestinal tissues.共同黏膜免疫系统的证据。II. 发情周期对B免疫母细胞迁移至生殖和肠道组织的影响。
J Immunol. 1980 Jun;124(6):2536-9.
10
The effect of length of incubation on adherence of group B streptococci to epithelial cells.孵育时间对B族链球菌黏附上皮细胞的影响。
Folia Microbiol (Praha). 1983;28(3):241-3. doi: 10.1007/BF02884088.