Döhlemann C, Güntner M, Vogel M
Fortschr Med. 1984 Oct 25;102(40):1009-12.
Owing to its positive inotropic action, digitalis is indicated in congestive heart failure; because of its effect on AV conduction it can also be used in arrhythmias. However the nature of the dysrhythmia and the underlying causes of congestive heart failure and arrhythmia need to be further differentiated. Any underlying disease (e.g. renal failure) must be treated primarily. Also, the value of inotropic agents in obstructive lesions needs to be considered. In cardiac arrhythmias digitalis can elicit potentially dangerous arrhythmias owing to AV block. Shortening of the refractory period of "bypass tracts" and by changing automaticity in autonomic focus atrial tachycardia. The possibility of interactions with such commonly used antiarrhythmic drugs as quinidine and amiodarone must be considered. All patients receiving digitalis should be carefully followed and monitored using physical examination, ECG, echocardiographic assessments and digitalis blood level determinations.
由于洋地黄具有正性肌力作用,可用于治疗充血性心力衰竭;因其对房室传导的影响,也可用于心律失常。然而,心律失常的性质以及充血性心力衰竭和心律失常的潜在病因需要进一步鉴别。任何潜在疾病(如肾衰竭)必须首先得到治疗。此外,还需要考虑正性肌力药物在梗阻性病变中的价值。在心律失常方面,洋地黄可因房室传导阻滞引发潜在危险的心律失常。缩短“旁路通道”的不应期,并改变自主神经节心房性心动过速的自律性。必须考虑与常用抗心律失常药物如奎尼丁和胺碘酮相互作用的可能性。所有接受洋地黄治疗的患者都应通过体格检查、心电图、超声心动图评估和洋地黄血药浓度测定进行仔细随访和监测。