小鼠体细胞中对刚地弓形虫细胞免疫的特异性介导作用。
Specific mediation of cellular immunity to Toxoplasma gondii in somatic cells of mice.
作者信息
Chinchilla M, Frenkel J K
出版信息
Infect Immun. 1984 Dec;46(3):862-6. doi: 10.1128/iai.46.3.862-866.1984.
Abstract
Lymphocytes from mice immunized against Toxoplasma gondii protected T. gondii-infected macrophage and kidney cell cultures. After contact with antigens, supernatants of such immune lymphocytes, also contained a factor protective for T. gondii-infected macrophages and kidney cells. Supernatants were protective only when the lymphocytes and kidneys cells were isogeneic. Protection was specific in that supernatants from only T. gondii-immune, but not Besnoitia jellisoni-immune, lymphocytes provided protection against toxoplasmosis. Sixteen to 24 h were required for an appreciable amount of protective factor to be secreted; a similar absorption time was necessary for kidney cells to be protected. Peritoneal lymphocyte lysates, prepared as transfer factor, contained protective substances with a potency similar to that of lymphocyte supernatants, which were also strain restricted in their effect.
摘要
用抗刚地弓形虫免疫的小鼠淋巴细胞可保护受刚地弓形虫感染的巨噬细胞和肾细胞培养物。与抗原接触后，这种免疫淋巴细胞的上清液也含有一种对受刚地弓形虫感染的巨噬细胞和肾细胞有保护作用的因子。仅当淋巴细胞和肾细胞是同基因时，上清液才有保护作用。这种保护具有特异性，因为只有来自刚地弓形虫免疫而非耶氏贝斯诺虫免疫的淋巴细胞的上清液才能提供针对弓形虫病的保护。需要16至24小时才能分泌出可观量的保护因子；肾细胞得到保护也需要类似的吸收时间。作为转移因子制备的腹膜淋巴细胞裂解物含有保护物质，其效力与淋巴细胞上清液相似，其作用也具有菌株限制性。
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