Mielens Z E, Gorman W G
Int Arch Allergy Appl Immunol. 1984;75(4):368-74. doi: 10.1159/000233649.
Dose-related impairment of pulmonary functions was induced in artificially respired, anesthetized cynomolgus monkeys by inhalation of aerosolized Ascaris antigen (AA) in ascending doses. The effects of pharmacologic agents were assessed by increases in threshold Ascaris dose (TAD). TAD were defined as the doses of AA needed for 20% increase in pulmonary resistance and 15% decrease in compliance. Inhaled FPL 55712, an SRS-A antagonist (1.24 mg through-the-valve dose; TTVD), and 5,8,11,14-eicosatetraynoic acid (ETYA), an inhibitor of lipoxygenase and cyclooxygenase (1.0 mg TTVD) resulted in significant increases in the geometric means of TAD for changes in compliance (p less than 0.01). The effects of both agents upon resistance were of borderline significance. Orally administered aminophylline (30 mg/kg) had no significant effect upon mean TAD for resistance or compliance. The activities of FPL 55712 and ETYA suggest that spasmogenic leukotrienes are involved in the pulmonary allergic reactions in cynomolgus monkeys.
通过吸入递增剂量的雾化蛔虫抗原（AA），在人工呼吸、麻醉的食蟹猴中诱导出与剂量相关的肺功能损害。通过阈值蛔虫剂量（TAD）的增加来评估药物制剂的效果。TAD定义为使肺阻力增加20%和顺应性降低15%所需的AA剂量。吸入FPL 55712（一种SRS-A拮抗剂，经阀门剂量为1.24毫克）和5,8,11,14-二十碳四烯酸（ETYA，一种脂氧合酶和环氧化酶抑制剂，经阀门剂量为1.0毫克）导致顺应性变化的TAD几何平均值显著增加（p小于0.01）。两种药物对阻力的影响具有临界显著性。口服氨茶碱（30毫克/千克）对阻力或顺应性的平均TAD没有显著影响。FPL 55712和ETYA的活性表明，致痉挛白三烯参与了食蟹猴的肺部过敏反应。
