O'Neil R M, Goodman F R
J Allergy Clin Immunol. 1981 Mar;67(3):229-36. doi: 10.1016/0091-6749(81)90066-x.
Responses to Ascaris antigen were evaluated in rhesus and cynomolgus monkeys. Of 19 cynomolgus monkeys tested, 15 were found to have cutaneous reactivity to Ascaris: 13 of these responded to Ascaris aerosols with changes in respiratory function including an increase in respiration rate, decrease in tidal volume and peak expiratory flow rate, decrease in dynamic compliance, and an increase in resistance. Four of the six rhesus monkeys studied with cutaneous reactivity to Ascaris responded to Ascaris aerosols: the changes in respiratory function observed after the Ascaris challenge in these monkeys were similar to those observed in the cynomolgus monkeys. Responses to repetitive Ascaris challenges were obtained in monkeys of both species with a recovery period of 30 to 60 min between challenges. In monkeys of both species that reacted to Ascaris aerosols, blood pressure was elevated transiently; changes in heart rate were variable. Changes in cardiovascular measurements were not observed in monkeys that did not respond to Ascaris aerosols. Thus, it appears that the cynomolgus monkey responds to an aerosol Ascaris challenge in a manner similar to the rhesus monkey and is an additional suitable model for the study of allergic respiratory responses.
在恒河猴和食蟹猴中评估了对蛔虫抗原的反应。在接受测试的19只食蟹猴中，发现15只对蛔虫有皮肤反应性：其中13只对蛔虫气雾剂有反应，呼吸功能发生变化，包括呼吸频率增加、潮气量和呼气峰值流速降低、动态顺应性降低以及阻力增加。在研究的6只对蛔虫有皮肤反应性的恒河猴中，有4只对蛔虫气雾剂有反应：这些猴子在接受蛔虫激发后观察到的呼吸功能变化与食蟹猴中观察到的相似。在两个物种的猴子中，在两次激发之间有30至60分钟的恢复期的情况下，获得了对重复蛔虫激发的反应。在对蛔虫气雾剂有反应的两个物种的猴子中，血压短暂升高；心率变化不定。在对蛔虫气雾剂无反应的猴子中未观察到心血管测量值的变化。因此，看来食蟹猴对气雾剂蛔虫激发的反应方式与恒河猴相似，是研究过敏性呼吸道反应的另一个合适模型。
