Mingardi G, Perico N, Pusineri F, Massazza M, Marchesi E, Mecca G, Remuzzi G, Donati M B
Int J Artif Organs. 1984 Sep;7(5):269-74.
Anticoagulation of extracorporeal circuit still represents a major problem for hemodialysis units. Uraemic patients are at risk of hemorrhages, so anticoagulant could increase such a risk. On the other hand clotting of extracorporeal circuit may complicate inadequate heparin administration or hemostatic activation by the foreign surfaces. In this article we propose a simple standard for heparin administration and monitoring which allows the theoretical best anticoagulation for extracorporeal circuit. Our data also indicate that the effect of our proposed schedule is not influenced by the type of membrane or dialyser used.
体外循环的抗凝问题仍然是血液透析单位面临的一个主要问题。尿毒症患者有出血风险，因此抗凝剂可能会增加这种风险。另一方面，体外循环的凝血可能会使肝素给药不足或异物表面的止血激活复杂化。在本文中，我们提出了一种简单的肝素给药和监测标准，该标准可为体外循环提供理论上最佳的抗凝效果。我们的数据还表明，我们提出的方案的效果不受所用膜或透析器类型的影响。
