完全肝素化血液透析系统在尿毒症患者中的临床应用。

Clinical use of a totally heparin grafted hemodialysis system in uremic patients.

Schmer G, Teng L N, Vizzo J E, Graefe U, Milutinovich J, Cole J J, Scribner B H

Trans Am Soc Artif Intern Organs. 1977;23:177-84. doi: 10.1097/00002480-197700230-00048.

Abstract

A totally heparin grafted dialysis system shows great promise in the treatment of chronic uremia associated with bleeding risk. 2. Long-term treatment of chronic uremia with this system has to await: a) Further studies of the chronic toxicity of CPC. b) Evaluation of performance which may be achieved by using a more homogeneous heparin with higher bioactivity. 3. Detailed studies of platelet factor 4 release with subsequent heparin neutralization to determine the importance of this variable in its effect on system performance.

摘要

一个完全肝素化的透析系统在治疗伴有出血风险的慢性尿毒症方面显示出巨大潜力。2. 使用该系统对慢性尿毒症进行长期治疗尚需等待：a) 对CPC慢性毒性的进一步研究。b) 对使用具有更高生物活性的更均匀肝素可能实现的性能评估。3. 对血小板因子4释放以及随后肝素中和进行详细研究，以确定该变量对系统性能影响的重要性。