Shah S J, Bhandarkar S D, Satoskar R S
Int J Clin Pharmacol Ther Toxicol. 1984 Sep;22(9):470-2.
Diabetics well controlled on chlorpropamide received, in randomized manner either 1200 mg of ibuprofen or 300 mg of phenylbutazone per day for rheumatic pains, for a period of 4 weeks. Fasting and postlunch, whole blood, true sugars (FBS and PLBS) were estimated at weekly intervals. Subjects taking phenylbutazone showed reduction in FBS values throughout the treatment; the reduction became statistically significant at the 3rd and 4th week. Clinical hypoglycemia, however, was not observed. The FBS values returned to pretreatment levels after stopping phenylbutazone. No significant reduction was seen in FBS in subjects taking ibuprofen. There was no significant change in PLBS values in either group.
服用氯磺丙脲且病情得到良好控制的糖尿病患者，以随机方式每天服用1200毫克布洛芬或300毫克保泰松来治疗风湿性疼痛，为期4周。每周测定空腹及午餐后全血中的实际血糖值（空腹血糖和午餐后血糖）。服用保泰松的受试者在整个治疗期间空腹血糖值均有下降；在第3周和第4周时，这种下降具有统计学意义。然而，未观察到临床低血糖情况。停用保泰松后，空腹血糖值恢复到治疗前水平。服用布洛芬的受试者空腹血糖值未见显著下降。两组的午餐后血糖值均无显著变化。
