Ritschel W A, Mandybur T I, Grummich K W, Means E D
Methods Find Exp Clin Pharmacol. 1984 Mar;6(3):131-4.
Unilateral ligation of the common carotid artery was performed in 134 gerbils. Study I was comprised of 60 controls and 60 animals receiving I.P. vincamine 1 mg/kg q4h. In a small second study 14 animals received vincamine I.P. 40 mg/kg q12h. In all groups ligation of the carotid artery was performed 6 days after starting dosing. The animals were observed for a further 6 days after carotid artery ligation. Whereas vincamine had no effect on the percent of animals in each group dying after carotid ligation, the extent of stroke lesion, measured histometrically, was significantly reduced (P less than 0.05) in the vincamine treated animals.
对134只沙鼠进行了颈总动脉单侧结扎。研究I包括60只对照组动物和60只腹腔注射长春胺（1毫克/千克，每4小时一次）的动物。在第二项小型研究中，14只动物腹腔注射长春胺（40毫克/千克，每12小时一次）。在所有组中，给药6天后进行颈动脉结扎。颈动脉结扎后，对动物再观察6天。虽然长春胺对每组中颈动脉结扎后死亡动物的百分比没有影响，但通过组织测量法测得的中风损伤程度在长春胺治疗的动物中显著降低（P<0.05）。
