van der Westhuyzen J, Gibson J E
Int J Vitam Nutr Res. 1984;54(2-3):205-10.
The fruit bat Rousettus aegyptiacus, when exposed to nitrous oxide (N2O) for 8-10 weeks develops cobalamin deficiency and neurological impairment leading to ataxia and death. We report the lipid composition of cerebral tissue of control animals and impaired animals following exposure to N2O, with or without dietary folic acid supplements. There were no statistically significant differences in the concentrations of total lipids, phospholipid, glycosphingolipid, plasmalogen and cholesterol between the different groups, although the ratio of choline phosphoglyceride to ethanolamine phosphoglyceride in N2O exposed animals was slightly lower than in controls. Bats exposed to N2O showed slightly higher levels of the fatty acid linoleate (18:2) in their phosphatidylethanolamine relative to arachidonate (20:4) compared with controls. This increase tended to be more pronounced in the bats receiving dietary folic acid supplements (but p greater than 0.05).
埃及果蝠（Rousettus aegyptiacus）在暴露于一氧化二氮（N2O）8至10周后会出现钴胺素缺乏和神经功能障碍，导致共济失调和死亡。我们报告了对照动物以及暴露于N2O且有或没有膳食叶酸补充剂的受损动物脑组织的脂质组成。不同组之间总脂质、磷脂、糖鞘脂、缩醛磷脂和胆固醇的浓度没有统计学上的显著差异，尽管暴露于N2O的动物中胆碱磷酸甘油酯与乙醇胺磷酸甘油酯的比例略低于对照组。与对照组相比，暴露于N2O的蝙蝠其磷脂酰乙醇胺中的脂肪酸亚油酸（18:2）水平相对于花生四烯酸（20:4）略高。在接受膳食叶酸补充剂的蝙蝠中，这种增加往往更为明显（但p大于0.05）。
