Shimada H, Imada T, Kikuchi T, Inada Y, Morisaki M, Ikekawa N, Saito Y
J Appl Biochem. 1984 Jun;6(3):151-5.
The effect of oxygenated sterols on platelet aggregation induced by thrombin and ADP has been studied. All oxygenated sterols tested with a hydroxyl group on the side chain enhanced thrombin-induced aggregation at 25 microM. In the case of ADP-induced aggregation, however, only 22S-hydroxycholesterol[(22S)-5-cholestene-3 beta,22-diol] enhanced the aggregation, and 22R-hydroxycholesterol[(22R)-5-cholestene-3 beta,22-diol], 24S-hydroxycholesterol[(24S)-5-cholestene-3 beta,24-diol], and 25-hydroxycholesterol[5-cholestene-3 beta,25-diol] inhibited it. These effects were observed within 10 min after the addition of oxygenated sterols to platelet suspensions in plasma.
已对氧化甾醇对凝血酶和二磷酸腺苷（ADP）诱导的血小板聚集的影响进行了研究。所有在侧链带有羟基的测试氧化甾醇在25微摩尔浓度时均增强了凝血酶诱导的聚集。然而，在ADP诱导的聚集中，只有22S-羟基胆固醇[（22S）-5-胆甾烯-3β，22-二醇]增强了聚集，而22R-羟基胆固醇[（22R）-5-胆甾烯-3β，22-二醇]、24S-羟基胆固醇[（24S）-5-胆甾烯-3β，24-二醇]和25-羟基胆固醇[5-胆甾烯-3β，25-二醇]则抑制了聚集。在向血浆中的血小板悬浮液添加氧化甾醇后的10分钟内观察到了这些效应。
