蛋白聚糖（PG）和糖胺聚糖（GAG）对二磷酸腺苷（ADP）、胶原和凝血酶诱导的血小板聚集的影响。

Influence of proteoglycans (PG) and glycosaminoglycans (GAG) on ADP-, collagen- and thrombin-induced platelet aggregation.

作者信息

Klein K, Sinzinger H, Silberbauer K, Stachelberger H, Leithner C

出版信息

Artery. 1980;8(5):410-5.

Abstract

PGs and GAGs have been isolated from fresh bovine aortas according to the method of Hascall and chemically characterized. These PGs and GAGs had only little effects on ADP- and collagen-induced platelet aggregation, but had very potent inhibitory action on thrombin-induced platelet aggregation and prolonged thrombin-clotting-time. Of the standard GAGs investigated hyaluronic acid, chondroitin-4-sulfate and chondroitin-6-sulfate had only little inhibitory action on thrombin-induced platelet aggregation, whereas heparin was very potent in this respect. The unsaturated disaccharides originating after degradation of GAGs with chondroitinases had no effect on platelet aggregation. No differences between PGs and GAGs in inhibiting thrombin-induced platelet aggregation could be detected.

摘要

已根据哈斯卡尔的方法从新鲜牛主动脉中分离出前列腺素（PGs）和糖胺聚糖（GAGs），并进行了化学表征。这些PGs和GAGs对二磷酸腺苷（ADP）和胶原诱导的血小板聚集影响很小，但对凝血酶诱导的血小板聚集具有非常强的抑制作用，并延长了凝血酶凝血时间。在所研究的标准GAGs中，透明质酸、硫酸软骨素-4和硫酸软骨素-6对凝血酶诱导的血小板聚集抑制作用很小，而肝素在这方面作用很强。用软骨素酶降解GAGs后产生的不饱和二糖对血小板聚集没有影响。在抑制凝血酶诱导的血小板聚集方面，未检测到PGs和GAGs之间的差异。