Ford B L, Wall A K, Johnston M A, Lea A R
J Assoc Off Anal Chem. 1984 Sep-Oct;67(5):934-9.
A major impurity in a sample of propantheline bromide tablets has been identified as 9-hydroxypropantheline on the basis of the proton magnetic resonance (PMR) and mass spectra (MS). This identification was confirmed by methanolysis of the tablet extract, which yielded a mixture of methyl xanthanoate and methyl 9-hydroxyxanthanoate. A liquid chromatographic (LC) procedure is described which will permit quantitation of 9-hydroxypropantheline bromide in the presence of propantheline bromide, xanthone, and xanthanoic acid.
基于质子磁共振（PMR）和质谱（MS），已鉴定出溴丙胺太林片样品中的一种主要杂质为9-羟基溴丙胺太林。通过片剂提取物的甲醇分解对此鉴定进行了确认，甲醇分解产生了黄原酸甲酯和9-羟基黄原酸甲酯的混合物。本文描述了一种液相色谱（LC）方法，该方法可在存在溴丙胺太林、呫吨酮和呫吨酸的情况下对9-羟基溴丙胺太林进行定量分析。
