Henauer S A, Gillespie H K, Hollister L E
J Clin Psychiatry. 1984 Dec;45(12):512-5.
Ten subjects were treated with 30 and 60 mg oral doses of yohimbine hydrochloride or placebo under controlled clinical conditions to determine if such doses would create a "model anxiety state." Some evidence of anxiety was found on various rating scales, especially after the 60 mg dose. However, maximum anxiety produced by this dose of the drug exceeded that which occurred during placebo testing in only 5 of the 10 subjects. The 60 mg dose produced substantial increases in systolic blood pressure and less increase in diastolic blood pressure and pulse rate. It was concluded that yohimbine does not produce a very good model of anxiety.
在对照临床条件下，对10名受试者口服30毫克和60毫克盐酸育亨宾或安慰剂，以确定这些剂量是否会产生“模型焦虑状态”。在各种评分量表上发现了一些焦虑迹象，尤其是在服用60毫克剂量后。然而，该剂量药物产生的最大焦虑仅在10名受试者中的5名中超过了安慰剂测试期间出现的焦虑。60毫克剂量使收缩压大幅升高，舒张压和脉搏率升高较少。得出的结论是，育亨宾不能产生很好的焦虑模型。
