Smith A R
J Embryol Exp Morphol. 1978 Apr;44:105-12.
Digit regeneration has been examined in Triturus cristatus. Because of their size, blastemas that form after digit amputation are relatively a lot more suitable for quantitative studies that involve for example the counting of cells in histological sections. They are also very useful for the study of some basic histological aspects of regeneration particularly cartilage formation. This has been looked at in regenerating digits, as there are only a maximum of three bones to regenerate and these lie in sequence, one after the other. It was seen that the cartilage is laid down as a solid rod by about 17 days post-amputation, and that by about 20 days, it starts to be split up into its three elements. An X-ray study of the growth of digit regeneration together with autoradiography experiments were also carried out as a comparison to studies already undertaken on larger more proximal blastemas. It was shown that in fact the behaviour of digit blastemas is very similar to those of a more proximal origin. This fact, together with the advantages of its size, make the digit a very strong candidate for the further study of regeneration.
已经对有冠蝾螈的指再生进行了研究。由于其大小，指截肢后形成的芽基相对更适合进行定量研究，例如对组织切片中的细胞进行计数。它们对于研究再生的一些基本组织学方面，特别是软骨形成也非常有用。这一点在再生指中得到了研究，因为最多只有三块骨头需要再生，而且它们依次排列。可以看到，截肢后约17天时软骨以实心棒的形式形成，到约20天时，它开始分裂成三个部分。还进行了指再生生长的X射线研究以及放射自显影实验，作为与已对更大、更靠近近端的芽基进行的研究的比较。结果表明，实际上指芽基的行为与起源更靠近近端的芽基非常相似。这一事实，连同其大小的优势，使得指成为再生进一步研究的有力候选对象。
