γ-羧基谷氨酸存在于一种神经活性毒素中。
Gamma-carboxyglutamate in a neuroactive toxin.
作者信息
McIntosh J M, Olivera B M, Cruz L J, Gray W R
出版信息
J Biol Chem. 1984 Dec 10;259(23):14343-6.
PMID:6501296
Abstract
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
摘要
一种以鱼为食的芋螺（地纹芋螺）的毒液中含有一种新型毒素——“睡眠者”肽，当脑内注射时，它会在小鼠体内诱导出类似睡眠的状态。我们证明，这种肽在17个氨基酸中含有5摩尔的γ-羧基谷氨酸（Gla）。“睡眠者”肽的氨基酸序列为甘氨酸-谷氨酸-Gla-Gla-亮氨酸-谷氨酰胺-Gla-天冬酰胺-谷氨酰胺-Gla-亮氨酸-异亮氨酸-精氨酸-Gla-赖氨酸-丝氨酸-天冬酰胺-NH2。
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