野生型和突变型利什曼原虫（Ld）抗原在L细胞中的侧向扩散。
Lateral diffusion of wild-type and mutant Ld antigens in L cells.
作者信息
Edidin M, Zuniga M
出版信息
J Cell Biol. 1984 Dec;99(6):2333-5. doi: 10.1083/jcb.99.6.2333.
Abstract
We have compared the lateral diffusion of intact transmembrane proteins, wild-type H-2Ld antigens, with that of mutants truncated in the cytoplasmic domain. Diffusion coefficients and mobile fractions were similar for all molecules examined, from wild-type Ld antigens with 31 residues on the cytoplasmic side of the plasma membrane to mutants with only four residues in the cytoplasmic domain. This result limits ways in which the lateral diffusion of a major histocompatibility antigen, a transmembrane protein, can be constrained by interactions with other molecules.
摘要
我们比较了完整跨膜蛋白野生型H-2Ld抗原与细胞质结构域截短的突变体的侧向扩散情况。对于所检测的所有分子，从质膜细胞质侧有31个残基的野生型Ld抗原到细胞质结构域仅有4个残基的突变体，扩散系数和可移动部分都相似。这一结果限制了主要组织相容性抗原（一种跨膜蛋白）的侧向扩散受与其他分子相互作用制约的方式。
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