Eysel U T, Wolfhard U
J Comp Neurol. 1984 Oct 20;229(2):301-9. doi: 10.1002/cne.902290214.
The nasal parts of the adult cat retina were photocoagulated. In the dorsal lateral geniculate nucleus (dLGN) the projection of the remaining innervation was shown by anterograde transport of 3H-proline after eye injections. The neuronal activity was measured from single cells across the border region between innervated and deafferented parts of layer A of the dLGN contralateral to the lesions. A gradual decrease from normal light-excitability to total inexcitability was observed over a range of 300 micron. The perikaryal cell sizes measured in the same part of the dLGN displayed a concomitant decrease. Blockage of the afferent impulses by chronic application of tetrodotoxin did not change the results, suggesting that it is the loss of connections, not the loss of activity, that produces the transneuronal atrophy in the adult cat dLGN.
对成年猫视网膜的鼻侧部分进行了光凝。在眼内注射³H - 脯氨酸后，通过顺行运输在背侧外侧膝状体核（dLGN）中显示了剩余神经支配的投射。在与损伤对侧的dLGN的A层的神经支配和去传入部分之间的边界区域，从单个细胞测量神经元活动。在300微米的范围内观察到从正常光兴奋性逐渐降低到完全无兴奋性。在dLGN的同一部分测量的胞体细胞大小也随之减小。长期应用河豚毒素阻断传入冲动并没有改变结果，这表明是连接的丧失而非活动的丧失导致了成年猫dLGN中的跨神经元萎缩。
