Farrow P R, Nicholson K G
J Infect. 1984 Sep;9(2):157-60. doi: 10.1016/s0163-4453(84)91156-3.
The effects on anticoagulation of a purified trivalent sub-unit influenza vaccine and a 14-valent pneumococcal vaccine were investigated in a single-blind controlled study involving 69 well-stabilised warfarin recipients. There were no clinically or statistically significant alterations of anticoagulant control in vaccine recipients as compared with controls at 2, 7 and 21 days after vaccination. On the basis of these data, concern about warfarin-vaccine interaction should not deter practitioners from immunising warfarin recipients against influenza or infection with Streptococcus pneumoniae.
在一项涉及69名华法林剂量稳定的接受者的单盲对照研究中，对一种纯化的三价亚单位流感疫苗和一种14价肺炎球菌疫苗的抗凝作用进行了研究。与对照组相比，疫苗接种者在接种后2天、7天和21天的抗凝控制情况在临床和统计学上均无显著变化。基于这些数据，对于华法林与疫苗相互作用的担忧不应阻碍医生为服用华法林的患者接种流感疫苗或预防肺炎链球菌感染。
