Stockman J A, Graeber J E, Clark D A, McClellan K, Garcia J F, Kavey R E
J Pediatr. 1984 Nov;105(5):786-92. doi: 10.1016/s0022-3476(84)80308-x.
This study was undertaken to determine the factors that are important in determining the erythropoietin response in low-birth-weight infants during the period of so-called anemia of prematurity. In the first weeks of life oxygen consumption in a group of 21 infants gradually increased as hemoglobin level fell. The magnitude of the erythropoietin response inversely varied with the central venous oxygen tension (P-vO2) (r = -0.55, P less than 0.001). When the P-vO2 declined to less than 30 torr, erythropoietin values were uniformly increased above the "normal" range (defined as the values associated with P-vO2 greater than 38 torr). Erythropoietin values varied inversely with hemoglobin but in general did not exceed the values observed for normal adult men. The erythropoietin values in the infants were remarkably lower at any given hemoglobin level when compared with those of older children with anemia resulting from bone marrow failure. In general, elevations of erythropoietin were seen when the hemoglobin concentration declined to less than 10.0 gm/dl. Change in heart rate did not appear to be a reliable indicator of the presence of anemia; rather, it correlated best with oxygen consumption.
本研究旨在确定在所谓的早产儿贫血期间，对低体重婴儿促红细胞生成素反应起重要作用的因素。在出生后的头几周，21名婴儿的耗氧量随着血红蛋白水平的下降而逐渐增加。促红细胞生成素反应的幅度与中心静脉血氧张力（P-vO2）呈负相关（r = -0.55，P < 0.001）。当P-vO2降至低于30托时，促红细胞生成素值一致升高至“正常”范围以上（定义为与P-vO2大于38托相关的值）。促红细胞生成素值与血红蛋白呈负相关，但一般不超过正常成年男性观察到的值。与骨髓衰竭导致贫血的大龄儿童相比，在任何给定血红蛋白水平下，婴儿的促红细胞生成素值都显著较低。一般来说，当血红蛋白浓度降至低于10.0克/分升时，促红细胞生成素会升高。心率变化似乎不是贫血存在的可靠指标；相反，它与耗氧量的相关性最佳。
