Brown M S, Garcia J F, Phibbs R H, Dallman P R
J Pediatr. 1984 Nov;105(5):793-8. doi: 10.1016/s0022-3476(84)80309-1.
Erythropoietin, hemoglobin, hematocrit, oxygen affinity (P50), and reticulocyte counts were measured weekly starting at 1 week of age in 10 very-low-birth-weight infants and on a single occasion in 15 healthy men. In the adults, "available oxygen" (derived from oxygen carrying capacity and P50) averaged 13.1 ml/dl blood and the mean erythropoietin level was 15.2 mU/ml. Erythropoietin levels in the infants were inversely related to concentration of hemoglobin, P50, and available oxygen. However, despite the much lower mean "available oxygen" of 9.3 ml/dl in the infants compared with that in adults (P less than 0.001), the mean erythropoietin value of 8.2 mU/ml in the infants was less than in adults (P less than 0.001). Furthermore, the erythropoietin response to decreased "available oxygen" was lowest in the least mature infants. VLBW infants often develop clinical evidence of hypoxia during the anemia of prematurity. The relatively low erythropoietin levels in relation to "available oxygen" are compatible with a decreased erythropoietin response to hypoxia compared with that in adults. Such a difference in response could be a contributing factor to the anemia of prematurity.
对10名极低出生体重儿从1周龄开始每周测量促红细胞生成素、血红蛋白、血细胞比容、氧亲和力（P50）和网织红细胞计数，对15名健康男性仅进行一次测量。在成年人中，“有效氧”（由携氧能力和P50得出）平均为每毫升血液13.1毫升，促红细胞生成素平均水平为15.2毫单位/毫升。婴儿的促红细胞生成素水平与血红蛋白浓度、P50和有效氧呈负相关。然而，尽管婴儿的平均“有效氧”为9.3毫升/分升，远低于成年人（P<0.001），但婴儿的促红细胞生成素平均值为8.2毫单位/毫升，低于成年人（P<0.001）。此外，最不成熟的婴儿对“有效氧”降低的促红细胞生成素反应最低。极低出生体重儿在早产儿贫血期间常出现缺氧的临床证据。与成年人相比，与“有效氧”相关的促红细胞生成素水平相对较低，这与促红细胞生成素对缺氧的反应降低是一致的。这种反应差异可能是早产儿贫血的一个促成因素。
