Zweygarth E, Ahmed J S, Rehbein G
J Parasitol. 1984 Aug;70(4):542-4.
The efficacy of halofuginone (DL-trans-7-bromo-6-chloro-3,3-(3-hydroxy-2-piperidyl) acetonyl-4-(3H) quinazolinone), Wellcome 993 C (2-hydroxy-3-cyclohexyl-1,4-naphthoquinone), and oxytetracycline, all of which have been shown to have a schizonticidal effect in the treatment of bovine theileriosis, and the babesicidal drug diminazene diaceturate, were tested against the schizont stages of Babesia equi in cell culture. The in vitro test system measured DNA synthesis in treated and untreated cell lines. Halofuginone (0.02 microgram/ml) and Wellcome 993 C (5 micrograms/ml) suppressed the incorporation of tritiated thymidine by more than 80%. Oxytetracycline was less effective, while diminazene diaceturate showed no notable effect. The insufficient schizonticidal activity may explain the failure of diminazene diaceturate to cure B. equi infections. Schizonticidal drugs either alone, or in combination with known babesicidal drugs, should be tested in the chemotherapy of B. equi infections.
卤夫酮（DL-反式-7-溴-6-氯-3,3-（3-羟基-2-哌啶基）丙酮基-4-（3H）喹唑啉酮）、惠尔康993 C（2-羟基-3-环己基-1,4-萘醌）和土霉素均已证明在治疗牛泰勒虫病时有裂殖体杀灭作用，还有杀巴贝斯虫药物二醋酰胺苯脒，针对马巴贝斯虫的裂殖体阶段在细胞培养中进行了测试。体外测试系统测量了处理过和未处理过的细胞系中的DNA合成。卤夫酮（0.02微克/毫升）和惠尔康993 C（5微克/毫升）使氚标记胸腺嘧啶的掺入抑制超过80%。土霉素效果较差，而二醋酰胺苯脒未显示出显著效果。裂殖体杀灭活性不足可能解释了二醋酰胺苯脒治疗马巴贝斯虫感染失败的原因。裂殖体杀灭药物单独使用或与已知的杀巴贝斯虫药物联合使用，都应在马巴贝斯虫感染的化疗中进行测试。
