Aminoff M J, Dedo H H, Izdebski K
J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):361-5. doi: 10.1136/jnnp.41.4.361.
The clinical features of 12 patients with spasmodic dysphonia are described. In 11 patients, the voice was strained, harsh, tight, and tremulous, and was low in volume and pitch. Speech, which was sometimes barely intelligible, was interrupted by irregular stoppages and catches of the voice; it required considerable effort, and was accompanied by facial grimacing. The dysphonia was part of a more widespread neurological disorder (idiopathic torsion dystonia) in one case, while it coexisted with blepharospasm in another, and with postural tremor in two. There was a buccolingual hyskinesia in another of these 11 patients, but this may have been related to her previous drug regime. In the twelfth patient, who had a familial tremor, the voice was characterised by marked breathiness, with intermittent aphonia. The disorder is probably due to a focal dystonia of the laryngeal musculature, and this would be consistent with the type of neurological disorders that were associated with it in our cases. Symptomatic benefit follows the therapeutic division of one of the recurrent laryngeal nerves, in selected cases.
本文描述了12例痉挛性发音障碍患者的临床特征。11例患者的声音紧张、刺耳、紧绷且颤抖，音量和音调较低。言语有时难以理解，会被不规则的停顿和声音卡顿打断；说话需要相当大的力气，还伴有面部抽搐。在1例患者中，发音障碍是更广泛的神经系统疾病（特发性扭转性肌张力障碍）的一部分，在另1例中与眼睑痉挛共存，在2例中与姿势性震颤共存。在这11例患者中的另1例存在颊舌运动障碍，但这可能与她之前的用药方案有关。第12例患者有家族性震颤，其声音的特点是明显的气息声，并伴有间歇性失音。这种疾病可能是由于喉部肌肉的局灶性肌张力障碍引起的，这与我们病例中与之相关的神经系统疾病类型是一致的。在某些病例中，对一侧喉返神经进行治疗性切断可带来症状改善。
