Liu J C, Feldkamp J R, White J L, Hem S L
J Pharm Sci. 1984 Oct;73(10):1355-8. doi: 10.1002/jps.2600731007.
Phosphate is specifically adsorbed by aluminum hydroxycarbonate by anion ligand exchange. IR analysis indicated that phosphate exchanged with specifically adsorbed carbonate. Adsorption is favored by low pH and is inversely related to particle size. Adsorption of phosphate decreases the rate of acid neutralization of aluminum hydroxycarbonate. The results are applied to the treatment of hyperphosphatemia and hypophosphatemia.
通过阴离子配体交换，磷酸盐被碱式碳酸铝特异性吸附。红外分析表明，磷酸盐与特异性吸附的碳酸盐发生了交换。低pH值有利于吸附，且吸附与颗粒大小呈负相关。磷酸盐的吸附降低了碱式碳酸铝的酸中和速率。这些结果被应用于高磷血症和低磷血症的治疗。
