Shirodkar S, Hutchinson R L, Perry D L, White J L, Hem S L
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana 47907.
Pharm Res. 1990 Dec;7(12):1282-8. doi: 10.1023/a:1015994006859.
The structure of nine commercially manufactured aluminum-containing adjuvants was investigated by X-ray diffraction, infrared spectroscopy, transmission electron micrography, and energy dispersive spectrometry. Seven samples which were labeled as aluminum hydroxide were identified as boehmite, a crystalline aluminum oxyhydroxide [AlO(OH)]. However, the degree of crystallinity varied between the samples. Two samples which were labeled as aluminum phosphate were found to be amorphous aluminum hydroxyphosphate. Buffer anions and sulfate anions substitute for hydroxyls in the amorphous aluminum hydroxide formed by the in situ alum precipitation method. Finally, the aluminum-containing adjuvant in diphtheria and tetanus toxoid, U.S.P., produced by three manufacturers was characterized.
通过X射线衍射、红外光谱、透射电子显微镜和能量色散光谱法对九种商业生产的含铝佐剂的结构进行了研究。七个标记为氢氧化铝的样品被鉴定为勃姆石，一种结晶氢氧化铝[AlO(OH)]。然而，样品之间的结晶度不同。两个标记为磷酸铝的样品被发现是无定形羟基磷酸铝。缓冲阴离子和硫酸根阴离子取代了原位明矾沉淀法形成的无定形氢氧化铝中的羟基。最后，对三家制造商生产的美国药典白喉和破伤风类毒素中的含铝佐剂进行了表征。
