An association between mitochondria and microtubules in synaptosomes and axon terminals of cerebral cortex.
作者信息
Chan K Y, Bunt A H
出版信息
J Neurocytol. 1978 Apr;7(2):137-43. doi: 10.1007/BF01217913.
PMID:650260
Abstract
A substantial number of synaptosomes prepared from rat cerebral cortex were found by electron microscopy to contain a horseshoe-shaped mitochondrion flanked by an arc of three to ten microtubules opposite the synaptic membrane specializations. The microtubules were replaced by characteristic paracrystals following the incubation of synaptosomes with vinblastine sulfate. A similar spatial organization of microtubules and mitochondria was also observed in some axon terminals of the cerebral cortex in situ. The significance of this novel observation is discussed with regard to the role of microtubules in axonal transport at the synaptic terminal and previous reports on the identification of tubulin in synaptosomes and subsynaptic structures.
摘要
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