Guerrero Munoz F, Fearon Z
J Toxicol Clin Toxicol. 1984;22(2):149-56. doi: 10.3109/15563658408992550.
Acetaminophen LD50 was two fold lower in female than male mice, the greater sensitivity of female mice for acetaminophen was also reflected in the serum enzyme levels of glutamic oxaloacetic and pyruvic transaminases (SGOT/SGPT), where the enhancement of both enzymes was higher in female than male mice. We could also observe the L-cysteine protection against the toxic effect of acetaminophen. Our results demonstrate that the lethal action of acetaminophen administrated either P.O. or S.C., is sex related.
对乙酰氨基酚的半数致死剂量在雌性小鼠中比雄性小鼠低两倍，雌性小鼠对乙酰氨基酚更高的敏感性也反映在血清谷氨酸草酰乙酸转氨酶和谷丙转氨酶（SGOT/SGPT）水平上，其中这两种酶在雌性小鼠中的升高幅度高于雄性小鼠。我们还可以观察到L-半胱氨酸对乙酰氨基酚毒性作用的保护作用。我们的结果表明，经口服或皮下注射给予的对乙酰氨基酚的致死作用与性别有关。
