Garin E H, Williams R L, Fennell R S, Richard G A
J Pediatr. 1978 Jul;93(1):138-40. doi: 10.1016/s0022-3476(78)80627-1.
Ten patients with idiopathic minimal lesion nephrotic syndrome were treated with indomethacin. Nine patients received the drug for five weeks and one patient for nine weeks. Indomethacin was administered in a dose of 1 mg/kg/day during the first week and 2 mg/kg/day, thereafter. At the end of the study, nine patients remained edematous and all had a urinary protein excretion greater than 50 mg/kg/day, within the nephrotic range. Indomethacin did not change the course of the disease and its use in the treatment of IMLNS is not advised.
十名特发性微小病变型肾病综合征患者接受了吲哚美辛治疗。九名患者接受该药物治疗五周，一名患者接受治疗九周。吲哚美辛在第一周的给药剂量为1毫克/千克/天，此后为2毫克/千克/天。研究结束时，九名患者仍有水肿，且所有人的尿蛋白排泄量均大于50毫克/千克/天，处于肾病范围内。吲哚美辛并未改变疾病进程，因此不建议将其用于特发性微小病变型肾病综合征的治疗。
